Hi, this is Zifeng. I build AI scientists for biomedicine, and I am now working toward AI that builds AI and recursively self-improve, then ultimately toward scientific superintelligence. My research focuses on two foundations:

Scientific Agents — developing agents that reason over scientific evidence and execute long-horizon workflows across literature review, trial design, patient recruitment, and biomedical data analysis [Nat. Commun. '24, npj Digit. Med. '25, Nat. Biomed. Eng. '26, Nat. Mach. Intell. '26]
Scientific World Models — building interactive models of patients, clinical trials, and scientific processes that provide grounded feedback for agent learning and evaluation [npj Digit. Med. '26, KDD '23, EMNLP '22, IJCAI '24]
Current Focus

Extending these foundations toward AI4AI and recursive self-improvement: AI scientists that design, train, evaluate, and improve scientific AI models, while co-evolving with scientific world models through experimentation, feedback, and reinforcement learning.

News

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Recent Talks

2026 Empowering Clinical Development with LLMs and AI Agents
DBMI @ Columbia · BIDS @ Yale · CSE @ CUHK · Tsinghua Medicine · Duke-NUS Medicine · CS @ Zhejiang · CS @ Tsinghua · SIGS @ Tsinghua · AI4S @ Peking · XtalPi
2025 Large language models for clinical trial design, execution, and analysis
AI for Health Webinar @ Sunlab, UIUC
2025 Medical scientific discovery in the era of large language models (Chinese)
HIT Webinar · Zuozhu's Lab @ Zhejiang University
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Selected Publications

TrialPanorama
Benchmarking and Developing Large Language Models Using One Million Clinical Trials
Zifeng Wang, Jiacheng Lin, Qiao Jin, Junyi Gao, Jathurshan Pradeepkumar, Pengcheng Jiang, Zhiyong Lu, Jimeng Sun.
npj Digital Medicine, 2026
[Paper] [Project] [Dataset] [Models]
News Coverage: Nature Biotechnology, MIT Technology Review, HyperAI
DeepEvidence
Empowering Biomedical Evidence Exploration and Synthesis with Deep Knowledge Graph Research
Zifeng Wang, Zheng Chen, Ziwei Yang, Xiao Wang, Qiao Jin, Yifan Peng, Zhiyong Lu, Jimeng Sun.
Nature Machine Intelligence, 2026
[Paper] [Code] [Dataset]
Data science copilots
Making Large Language Models Reliable Data Science Programming Copilots for Biomedical Research
Zifeng Wang, Benjamin Danek, Ziwei Yang, Zheng Chen, Jimeng Sun.
Nature Biomedical Engineering, 2026
[Paper] [Code] [Dataset]
News Coverage: Live Science
LEADS
A foundation model for human-AI collaboration in medical literature mining (LEADS)
Zifeng Wang, Lang Cao, Qiao Jin, Joey Chan, Nicholas Wan, Behdad Afzali, Hyun-Jin Cho, Chang-In Choi, Mehdi Emamverdi, Manjot K. Gill, Sun-Hyung Kim, Yijia Li, Yi Liu, Yiming Luo, Hanley Ong, Justin Rousseau, Irfan Sheikh, Jenny J. Wei, Ziyang Xu, Christopher M. Zallek, Kyungsang Kim, Yifan Peng, Zhiyong Lu, Jimeng Sun.
Nature Communications, 2025
[Paper] [Code] [Model] [Dataset]
Clinical evidence synthesis
Accelerating Clinical Evidence Synthesis with Large Language Models
Zifeng Wang, Lang Cao, Benjamin Danek, Qiao Jin, Zhiyong Lu, Jimeng Sun.
npj Digital Medicine, 2025
[Paper] [Dataset]
TrialGPT
Matching Patients to Clinical Trials with Large Language Models (TrialGPT)
Qiao Jin, Zifeng Wang, Charalampos S. Floudas, Fangyuan Chen, Changlin Gong, Dara Bracken-Clarke, Elisabetta Xue, Yifan Yang, Jimeng Sun, Zhiyong Lu.
Nature Communications, 2024
[Paper] [Code] [Dataset]
News Coverage: Nature, NIH News, NIH Director's Blog, Health Science Top 25 of 2024, POLITICO, AUA News, Azure Government, Informa, FedScoop, MSN

Media Coverage